Drug Standards
Apexbio Technology LLC Cabozantinib malate (XL184) 1140909-48-3 10mM (in 1mL DMSO)
Cabozantinib malate (XL184 CAS 1140909-48-3) is a small-molecule inhibitor targeting multiple receptor tyrosine kinases notably MET and VEGFR2 with reported IC50 values of 1 3 nM and 0 035 nM respectively It also inhibits additional kinases including RET FLT3 KIT AXL and TEK In cellular assays Cabozantinib shows inhibition of phosphorylation in kinases MET VEGFR2 KIT FLT3 and AXL Moreover Cabozantinib suppresses HMVEC cell-tube formation (IC50 6 7 nM) and attenuates hepatocyte growth factor-induced tumor cell invasion and migration This compound has demonstrated antiproliferative activity in several cancer cell lines supporting its application in oncology research environments
Apexbio Technology LLC Cabazitaxel 183133-96-2 100mg
Cabazitaxel (CAS 183133-96-2) is a semisynthetic compound derived from the natural precursor 10-deacetylbaccatin III belonging to the taxoid class of antineoplastic agents It exerts its biological effects primarily by stabilizing microtubules thus disrupting mitotic and interphase cellular functions and causing cell-cycle arrest leading to apoptosis Due to this microtubule-targeting activity cabazitaxel is extensively studied in oncology research particularly investigating chemoresistant tumor cell lines and therapeutic approaches for taxane-resistant cancers
eMolecules 98-92-0 | Niacinamide | Chem-Impex | MFCD00006395 | 122.127 | C6H6N2O | 98.000 | NC(=O)c1cccnc1 | 1kg | 112441745
Niacinamide | Chem-Impex | 98-92-0 | MFCD00006395 | 122.127 | C6H6N2O | 98.000 | NC(=O)c1cccnc1 | 1kg | 112441745
Apexbio Technology LLC Cabazitaxel 183133-96-2 50mg
Cabazitaxel (CAS 183133-96-2) is a semisynthetic compound derived from the natural precursor 10-deacetylbaccatin III belonging to the taxoid class of antineoplastic agents It exerts its biological effects primarily by stabilizing microtubules thus disrupting mitotic and interphase cellular functions and causing cell-cycle arrest leading to apoptosis Due to this microtubule-targeting activity cabazitaxel is extensively studied in oncology research particularly investigating chemoresistant tumor cell lines and therapeutic approaches for taxane-resistant cancers
Apexbio Technology LLC Donepezil HCl 120011-70-3 1g
Donepezil hydrochloride (CAS 120011-70-3) is an acetylcholinesterase (AChE) inhibitor belonging to the piperidine class characterized chemically by an N-benzylpiperidine moiety coupled with an indanone-based group It selectively inhibits AChE with an IC50 of approximately 6 7 nM while its activity toward butyrylcholinesterase (BuChE) is much weaker (IC50 7 4 M) Donepezil hydrochloride is approved by the FDA specifically for Alzheimer s disease (AD) where it has been demonstrated to improve cognitive function in patients with mild to moderate AD symptoms
Apexbio Technology LLC R788 disodium 1025687-58-4 100mg
R788 disodium (CAS 1025687-58-4) is a prodrug of the active metabolite R406 a selective inhibitor of spleen tyrosine kinase (Syk) Syk mediates signaling downstream of activated Fc and B-cell receptors (BCR) In vitro R406 suppresses constitutive and ligand-stimulated BCR signaling in diffuse large B-cell lymphoma (DLBCL) lines by inhibiting Syk autophosphorylation (SYK525/526) and associated phosphorylation of BLNK inducing apoptosis In vivo R788 reduces malignant B-cell proliferation and tumor progression in E -TCL1 mice Clinically R788 has shown utility in rheumatoid arthritis improving therapeutic response rates in phase II trials
Sigma Aldrich Fine Chemicals Biosciences Low-substituted hydroxypropylcellulose European Pharmacopoeia (EP) Reference Standard | 9004-64-2 | MFCD00132688 |
Low-substituted hydroxypropylcellulose European Pharmacopoeia (EP) Reference Standard | 9004-64-2 | MFCD00132688 |
U.S. Pharmacopeia Doxercalciferol, 54573-75-0, MFCD00871065, 2 x 20mg
Molecular formula C28H44O2, Molecular weight 412.65, Melting point/freezing point 296.6 - 307.4 °F (147 - 153 °C), Synonyms: 1alpha-Hydroxyergocalciferol, 1alpha-Hydroxyvitamin D2, (5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1’,3’-diol
Medchemexpress LLC Ganciclovir | 82410-32-0 | MFCD00870588 | >99.89% | 255.23 | 1 ML
Ganciclovir (BW 759) is a nucleoside analogue and an orally active antiviral agent. It is known for its activity against Cytomegalovirus (CMV), as well as other members of the herpes group and various DNA viruses. Ganciclovir effectively inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. It also demonstrates an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and has the ability to diffuse into the brain.
- Acts as an orally active antiviral agent
- Effective against Cytomegalovirus (CMV)
- Inhibits replication of human herpes viruses and adenoviruses
- Demonstrates activity against feline herpesvirus type-1
- Can diffuse into the brain
eMolecules 496775-62-3 | Eltrombopag Olamine | Target Molecule | MFCD22380664 | 564.643 | C29H36N6O6 | 0.000 | NCCO.NCCO.CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1 | 50mg | 376018976
Eltrombopag Olamine | Target Molecule | 496775-62-3 | MFCD22380664 | 564.643 | C29H36N6O6 | 0.000 | NCCO.NCCO.CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1 | 50mg | 376018976
Medchemexpress LLC Dabigatran impurity 5 | 1610758-22-9 | 10mg
Dabigatran impurity 5 is an impurity of Dabigatran (HY-10163)
Medchemexpress LLC Linagliptin impurity 9 | 2279114-27-9 | 25mg
Linagliptin impurity 9 is an impurity of Linagliptin (HY-10284)
Medchemexpress LLC Ibrutinib impurity 28 | 2213398-75-3 | MFCD34472115 | 10mg
Ibrutinib Impurity 28 is an impurity of Ibrutinib (HY-10997)